I’ve revisited my music writing and production skills, for some reason I wasn’t able to drag and drop “Components” on GuitarRig. Unable to find any solution I started to look for anything suspicious.
The drag and drop sometimes worked but to an arbitrary dropzone. So I considered that it was a miscalculation of the coordinates due to the Retina Display.
Opening both Reaper64(DAW) and GuitarRig5(Stand Alone) “Get info” window and setting the “Open in Low Resolution” checkbox fixed the issue.